Recent Progress and Developments in Chemoenzymatic and Biocatalytic Dynamic Kinetic Resolution
Li‐Cheng Yang, Heping Deng, Hans Renata
Abstract
Dynamic kinetic resolution (DKR) is a powerful method to construct complex molecules with one or more stereocenters. In light of their exquisite stereospecificity and stereoselectivity, enzymes are becoming widely used as catalysts in DKR. This review summarizes chemoenzymatic and biocatalytic methodologies for DKR that have been developed in the past decade. Additionally, applications of these methodologies in the preparation of active pharmaceutical ingredients and emerging paradigms, including the combined use of biocatalysis and photocatalysis for DKR, are highlighted.
Topics & Concepts
Kinetic resolutionBiocatalysisChemistryBiochemical engineeringStereocenterNanotechnologyCombinatorial chemistryOrganic chemistryCatalysisMaterials scienceEnantioselective synthesisEngineeringReaction mechanismEnzyme Catalysis and ImmobilizationAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis