The riddle of the Sphinx: why sphingosine‐1‐phosphate may help define molecular mechanisms underlying risk stratification for serious COVID‐19 infections
Hugh Rosen, Michael B. A. Oldstone
Abstract
The sphingosine-1-phosphate (S1P) is a lysophospholipid signaling molecule with important functions in many physiological and pathological conditions, including viral infection. In this issue of EMBO Molecular Medicine, Marfia et al present a risk stratification based on S1P serum level as a novel prognostic indicator for COVID-19 severity.
Topics & Concepts
Sphingosine-1-phosphateRisk stratificationCoronavirus disease 2019 (COVID-19)SphingosineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Stratification (seeds)Pathological2019-20 coronavirus outbreakBiologyMedicineVirologyInternal medicineDiseaseInfectious disease (medical specialty)BiochemistryReceptorDormancyGerminationBotanySeed dormancyOutbreakSphingolipid Metabolism and SignalingLipid Membrane Structure and BehaviorEndoplasmic Reticulum Stress and Disease