A ratiometric fluorescent probe for real-time monitoring of intracellular glutathione fluctuations in response to cisplatin
Hanzhuang Liu, Wenting Song, Shuren Zhang, Kin Shing Chan, Zijian Guo, Zhen Shen
Abstract
Real-time imaging of intracellular glutathione in response to cisplatin by a ratiometric fluorescent probe reveals that the different trends in intracellular GSH levels is crucial in distinguishing cisplatin-resistant from cisplatin-sensitive cells.
Topics & Concepts
IntracellularGlutathioneCisplatinFluorescenceChemistryBiophysicsBiochemistryBiologyMedicineInternal medicineChemotherapyEnzymeOpticsPhysicsSulfur Compounds in BiologyMolecular Sensors and Ion DetectionLuminescence and Fluorescent Materials