Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells
Diana Bričkutė, Cen Chen, Marta Braga, Chris Barnes, Ning Wang, Louis Allott, Eric O. Aboagye
Abstract
Lipofuscin deposits in senescence cells are visualised using the pathology stain Sudan Black B (SBB), an emerging biomarker of senescence. This work develops and evaluates a fluorine-18 derivative for positron emission tomography (PET) imaging.
Topics & Concepts
LipofuscinPositron emission tomographySenescenceBiomarkerStainPet imagingChemistryPathologyCell biologyNuclear medicineMedicineStainingBiochemistryBiologyTelomeres, Telomerase, and SenescenceAdvanced Fluorescence Microscopy TechniquesAdvanced biosensing and bioanalysis techniques