Efferent synaptic transmission at the vestibular type II hair cell synapse
Yu Zhou, J. Michael McIntosh, Soroush G. Sadeghi, Elisabeth Glowatzki
Abstract
Type II vestibular hair cells (HCs) receive inputs from efferent neurons in the brain stem. We used in vitro optogenetic and electrical stimulation of vestibular efferent fibers to study their synaptic inputs to type II HCs. Stimulation of efferents inhibited type II HCs, similar to efferent effects on cochlear HCs. We propose that efferent inputs adjust the contribution of signals from type I and II HCs to vestibular nerve fibers.
Topics & Concepts
EfferentVestibular systemNeuroscienceVestibular nerveEfferent NeuronOptogeneticsStimulationNeurotransmissionHair cellEfferent nerveAfferentSynapseBiologyChemistryCochleaBiochemistryReceptorHearing, Cochlea, Tinnitus, GeneticsPhotoreceptor and optogenetics researchMarine animal studies overview