5-aminolevulinate and CHIL3/CHI3L1 treatment amid ischemia aids liver metabolism and reduces ischemia-reperfusion injury
Guanghui Jin, Na Guo, Yasong Liu, Lele Zhang, Chen Liang, Tao Dong, Wei Liu, Xiaomei Zhang, Yong Jiang, Guo Lv, Fei Zhao, Wei Liu, Ziqing Hei, Yang Yang, Jingxing Ou
Abstract
Our results reveal that supplementing 5-ALA promotes macrophagic M2 polarization via downregulation of RelA and CX3CR1 in mice following HIR, while M2 macrophage-produced CHIL3/CHI3L1 also manifests beneficial effects to the recovery of hepatic metabolism. 5-ALA and CHIL3/CHI3L1 together mitigate HIR-induced mitochondrial dysfunction and hepatocellular injuries, which may be developed into safe and effective clinical treatments to attenuate HIR injuries.
Topics & Concepts
Liver injuryIschemiaReactive oxygen speciesReperfusion injuryMacrophage polarizationInflammationMetabolismHomeostasisBiologyPharmacologyChemistryImmunologyCell biologyMedicineBiochemistryInternal medicineMacrophageIn vitroMitochondrial Function and PathologyOrgan Transplantation Techniques and OutcomesLiver Disease and Transplantation