Impact of gold nanoparticle size and coating on radiosensitization and generation of reactive oxygen species in cancer therapy
E. Loscertales, Rosalía López‐Méndez, Joaquı́n Mateo, L. M. Fraile, J. M. Udı́as, Ana Espinosa, Samuel España
Abstract
production, suggesting that multiple reactive species contribute to the radiosensitization process. Clonogenic assays confirmed that PEG-capped AuNPs produced stronger radiosensitizing effects than citrate-capped AuNPs, with smaller AuNPs providing more pronounced biological effects. This study underscores the importance of conducting both chemical and biological evaluations to fully understand the radiosensitization efficacy of AuNPs.
Topics & Concepts
CoatingColloidal goldNanoparticleMaterials scienceReactive oxygen speciesNanotechnologyPEG ratioOxygenChemical engineeringChemistryBusinessBiochemistryOrganic chemistryEngineeringFinanceRadiation Therapy and DosimetryNanoplatforms for cancer theranosticsAdvanced Radiotherapy Techniques