Design, synthesis and biological evaluation of the tumor hypoxia-activated PROTACs bearing caged CRBN E3 ligase ligands
Weiyan Cheng, Shasha Li, Siyuan Han, Ruoyang Miao, Suhua Wang, Chunxia Liu, Wei Han, Xin Tian, Xiaojian Zhang
Topics & Concepts
ChemistryUbiquitin ligaseCereblonDNA ligaseProdrugTumor hypoxiaProteolysisHypoxia (environmental)In vitroHypoxia-inducible factorsApoptosisLigand (biochemistry)UbiquitinBiochemistryReceptorCell biologyPharmacologyEnzymeOxygenBiologyRadiation therapyGeneMedicineOrganic chemistryInternal medicineProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis