Molecular tumor testing in patients with Lynch-like syndrome reveals a de novo mosaic variant of a mismatch repair gene transmitted to offspring
Erell Guillerm, Magali Svrcek, Armelle Bardier–Dupas, Noémie Basset, Florence Coulet, Chrystelle Colas
Topics & Concepts
Lynch syndromeMSH2Microsatellite instabilityMLH1GeneticsBiologyDNA mismatch repairGermlineSomatic cellGermline mutationGeneMicrosatelliteMutationDNA repairAlleleGenetic factors in colorectal cancerCancer Genomics and DiagnosticsColorectal Cancer Screening and Detection