The Risk of QTc Prolongation with Antiemetics in the Palliative Care Setting: A Narrative Review
Elizabeth M. Gavioli, Nerli Guardado, Farah Haniff, Nouran Deiab, Etty Vider
Abstract
Nausea and vomiting are common within the palliative care population. Antiemetic agents may help control symptoms, but may also place patients at risk for QTc prolongation. This article reviews pharmacotherapy agents including anticholinergics, antihistamines, antidopaminergics, 5-HT3 receptor antagonists, dronabinol, and medical marijuana and their associated risk of QTc prolongation. A clinical treatment pathway is provided to help guide clinicians in choosing the most appropriate antiemetic based upon patient specific factors for QTc prolongation.
Topics & Concepts
MedicineAntiemeticQT intervalIntensive care medicinePalliative careNauseaDomperidoneVomitingLong QT syndromePharmacotherapyAnesthesiaClinical pharmacologyInternal medicinePharmacologyNursingDopamineNausea and vomiting managementPathogenesis and Treatment of HiccupsEpilepsy research and treatment