MiR-29a-3p Inhibits Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells via Targeting FOXO3 and Repressing Wnt/<i>β</i>-Catenin Signaling in Steroid-Associated Osteonecrosis
Changgeng Wang, Minghui Zhu, Demeng Yang, Xinyuan Hu, Xinyuan Wen, Aimei Liu
Abstract
Background and Objectives: This study was to investigate the role of microRNA-29a-3p (miR-29a-3p) in human bone marrow mesenchymal stem cells (hBMSCs), and its relationship with steroid-associated osteonecrosis. Methods and Results: -catenin to the nucleus. Conclusions: -catenin signaling to inhibit viability and osteogenic differentiation of hBMSCs, thereby promoting the development of steroid-associated osteonecrosis.
Topics & Concepts
Wnt signaling pathwayMesenchymal stem cellFOXO3Stem cellCell biologyCateninMedicineCancer researchSignal transductionBiologyProtein kinase BBone and Joint DiseasesCancer-related molecular mechanisms researchMicroRNA in disease regulation