Fusaric acid decreases p53 expression by altering promoter methylation and m6A RNA methylation in human hepatocellular carcinoma (HepG2) cells
Terisha Ghazi, Savania Nagiah, Anil A. Chuturgoon
Abstract
< 0.0001). Taken together, the data shows that FA epigenetically decreased p53 expression by altering its promoter methylation and m6A RNA methylation in HepG2 cells. This study reveals a mechanism for p53 regulation by FA and provides insight into future therapeutic interventions.
Topics & Concepts
RNA methylationBiologyFusaric acidMethylationDNA methylationMolecular biologyEpigeneticsRNACancer researchPost-transcriptional regulationMethyltransferasePromoterGene expressionDNAGeneBiochemistryGeneticsFusariumRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research