Effects of hesperidin on mitochondrial function, mitochondria-associated endoplasmic reticulum membranes and IP3R–MCU calcium axis in the intestine of piglets exposed to deoxynivalenol
Xin Li, Qian Lin, Feiyang Gou, Jiang Zhu, Minjie Yu, Qihua Hong, Caihong Hu
Abstract
inhibiting ER-mitochondrial calcium transfer mediated by IP3Rs. These data suggested that hesperidin could alleviate MAM-mediated mitochondrial calcium overload, thereby improving mitochondrial function and alleviating oxidative stress and intestinal injury in DON-challenged piglets.
Topics & Concepts
HesperidinMitochondrionEndoplasmic reticulumCalciumOxidative stressCell biologyChemistryFunction (biology)PharmacologyBiologyBiochemistryMedicinePathologyAlternative medicineOrganic chemistryRedox biology and oxidative stressGenomics, phytochemicals, and oxidative stressMitochondrial Function and Pathology