Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer
Nadja A. Simeth, Shotaro Kobayashi, Piermichele Kobauri, Stefano Crespi, Wiktor Szymański, Kazuhiko Nakatani, Chikara Dohno, Ben L. Feringa
Abstract
We present the rational design of photoswitchable DNA glue to trigger the reversible formation of duplex DNA by light. The supramolecular assembly shows a mutual interaction between ligand and DNA, which induces a preferred helicity in the switch.
Topics & Concepts
Rational designSupramolecular chemistryDNADuplex (building)Chirality (physics)ChemistrySupramolecular chiralityHelix (gastropod)Molecular machineNanotechnologyBiophysicsMaterials scienceCrystallographyBiologyPhysicsBiochemistryEcologySnailQuantum mechanicsChiral symmetry breakingNambu–Jona-Lasinio modelQuarkCrystal structurePhotochromic and Fluorescence ChemistryPhotoreceptor and optogenetics researchDNA and Nucleic Acid Chemistry