Gemini lipid nanoparticle (GLNP)-mediated oral delivery of TNF-α siRNA mitigates gut inflammation <i>via</i> inhibiting the differentiation of CD4<sup>+</sup> T cells
Priyanka Verma, Amit Arora, Kajal Rana, Devashish Mehta, Raunak Kar, Vikas Verma, Chittur V. Srikanth, Veena S. Patil, Avinash Bajaj
Abstract
cells. Therefore, this study highlights the potential of GLNPs derived from lithocholic acid-derived gemini cationic lipids for the development of next-generation nucleic acid delivery vehicles.
Topics & Concepts
ChemistryProinflammatory cytokineInflammationLithocholic acidTumor necrosis factor alphaCell biologyBiochemistryImmunologyBiologyBile acidRNA Interference and Gene DeliveryImmunotherapy and Immune ResponsesImmune Cell Function and Interaction