Engineered Multifunctional BioHJzyme via Tuning D‐Band Center for Postoperative Infected Wound Regeneration of Tumor Resection
Yi Deng, Xiaoke Lian, Zhijie Lin, Dan Sun, Haiyang Zou, Yau Kei Chan, Weizhong Yang, Miaomiao He, Guangfu Yin
Abstract
Abstract The catalytic therapy for abundant •OH, 1 O 2 , and •O 2 − provides an efficient tactic and methodology for rapid tumor/bacteria killing, whereas the limitation is focused on the catalytic efficiency owing to the in‐built energy band of catalytic materials. Thus, d‐band center tuning BioHJzyme is devised, which is composed of zinc tellurate/manganese dioxide anchored by glucose oxidase (GOx) with anti‐tumor and anti‐bacteria properties for postoperative infected wound regeneration of tumor. The GOx depletes glucose to produce H 2 O 2 , intercepting the glucose metabolism. The D‐BioHJzyme can catalyze the produced H 2 O 2 to highly lethal •OH with POD‐mimetic activity owing to the tunned d‐band center strategy decreasing the adsorption energy of the intermediate in the catalytical process, while the oxygen originated from H 2 O 2 and Mn 2+ can be catalyzed into 1 O 2 . The GPx‐mimetic activity of it can impair the antioxidant system of tumor. In vivo studies show that the BioHJzyme exhibits robust abilities against bacteria and tumors by •OH/ 1 O 2 production and promotes the apoptosis owing the Te. Besides, the BioHJzyme can accelerate cutaneous regeneration by M1/M2 regulation and the angiogenesis/collagen deposition. This work enlightens a powerful platform for the remedy of postoperative infected wound regeneration of tumor resection using an engineered BioHJzyme.