Target-induced clustering activates Trim-Away of pathogens and proteins
Jingwei Zeng, Ana Filipa Santos, Aamir S. Mukadam, Mariana Osswald, David A. Jacques, Claire F. Dickson, Stephen H. McLaughlin, C.M. Johnson, L. Kiss, Jakub Lupták, Nadine Renner, Marina Vaysburd, William A. McEwan, Eurico Morais‐de‐Sá, Dean Clift, Leo C. James
Topics & Concepts
Ubiquitin ligaseTrimCell biologyUbiquitinHuntingtin ProteinChemistryHEK 293 cellsProtein degradationMechanism (biology)BiologyHuntingtinReceptorBiochemistryGeneMutantComputer scienceEpistemologyPhilosophyOperating systemCAR-T cell therapy researchUbiquitin and proteasome pathwaysProtein Degradation and Inhibitors