Developing a far-red fluorogenic beta-galactosidase probe for senescent cell imaging and photoablation
Seung Koo Lee, Zhenhua Shen, Myung Shin Han, Ching‐Hsuan Tung
Abstract
A methylene blue (MB)-based beta-galactosidase (β-gal) activatable molecule, Gal-MB, was developed for senescence imaging and light-triggered senolysis.
Topics & Concepts
PhotoablationMethylene blueChemistryBiophysicsBiochemistryOpticsBiologyPhysicsLaserExcimer laserPhotocatalysisCatalysisAdvanced biosensing and bioanalysis techniquesTelomeres, Telomerase, and SenescenceNanoplatforms for cancer theranostics