Nickel‐ and Palladium‐Catalyzed Cross‐Coupling of Aryl Fluorosulfonates and Phosphites: Synthesis of Aryl Phosphonates
Guofu Zhang, Jing Wang, Chenfei Guan, Yiyong Zhao, Chengrong Ding
Abstract
Abstract The synthesis of aryl phosphonates via nickel and palladium‐catalyzed cross‐coupling of aryl fluorosulfonates and phosphites is described. The products were obtained in good to excellent yields under mild conditions with broad functional group compatibility, employing either Pd(OAc) 2 and DPEPhos or the readily available NiCl 2 (dme) and Xantphos as catalytic systems. Noteworthily, the present C(sp 2 )−P bond formation method could be applied to the direct conversion of phenols to the corresponding aryl phosphonates in one pot via reaction of phenols with SO 2 F 2 and subsequent palladium‐catalyzed cross‐coupling.
Topics & Concepts
XantphosArylPalladiumChemistryCatalysisPhenolsNickelCoupling reactionOrganic chemistryMedicinal chemistryCombinatorial chemistryPolymer chemistryAlkylCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis TechniquesChemical Synthesis and Reactions