Astaxanthin From Haematococcus pluvialis Prevents High-Fat Diet-Induced Hepatic Steatosis and Oxidative Stress in Mice by Gut-Liver Axis Modulating Properties
Meng Wang, Wenxin Xu, Jie Yu, Yingying Liu, Haotian Ma, Chunli Ji, Chunhui Zhang, Jinai Xue, Runzhi Li, Hongli Cui
Abstract
Scope: Evidence is mounting that astaxanthin (ATX), a xanthophyll carotenoid, used as a nutritional supplement to prevent chronic metabolic diseases. The present study aims to identify the potential function of ATX supplementation in preventing steatohepatitis and hepatic oxidative stress in diet-induced obese mice. Methods and Results: . Conclusion: The study results suggested that dietary ATX may prevent the development of hepatic steatosis and oxidative stress with the risk of metabolic disease by gut-liver axis modulating properties.
Topics & Concepts
SteatosisOxidative stressHaematococcus pluvialisAstaxanthinFatty liverEndocrinologyInternal medicineOxidative phosphorylationBiologyLiver metabolismChemistryMedicineBiochemistryCarotenoidDiseaseLiver Disease Diagnosis and TreatmentDiet and metabolism studiesAntioxidant Activity and Oxidative Stress