Organocatalytic cascade nucleophilic/aza-Michael addition reactions: metal-free catalytic strategy for the synthesis of hydantoins
Lei Xie, Lei Sun, Ping Wu, Zhaoxue Wang, Chenyi Zhao, Lingang Wu, Xiaojing Li, Zhenzhen Gao, Wanxing Liu, Shao‐Zhen Nie
Abstract
-alkoxy β-oxo-acrylamides with isocyanates has been developed to afford various highly functionalized hydantoin derivatives in 80-98% yields under mild reaction conditions. The intriguing features of this method include metal-free reaction conditions, low catalyst loading, broad substrate scope and short reaction time.
Topics & Concepts
NucleophileMichael reactionCatalysisLewis acids and basesChemistryHydantoinOrganic chemistryNucleophilic additionCombinatorial chemistryCascade reactionSubstrate (aquarium)OrganocatalysisBase (topology)Alkoxy groupCascadeEnantioselective synthesisMathematical analysisOceanographyMathematicsGeologyAlkylChromatographyChemical Synthesis and ReactionsSynthesis of heterocyclic compoundsSulfur-Based Synthesis Techniques