<scp>l</scp>-Theanine alleviates heat stress-induced impairment of immune function by regulating the p38 MAPK signalling pathway in mice
Yuan Hu, Ling Lin, Kehong Liu, Enshuo Liu, Shumin Han, Zhihua Gong, Wenjun Xiao
Abstract
). Treatment with L-theanine could attenuate the heat stress-induced reductions in body weight and feed intake in mice, alleviate damage in the liver and jejunum, and inhibit the inflammatory factors IL-6, IL-1β, and TNF-α. Aspartate aminotransferase and alanine transaminase activity levels and the malondialdehyde content decreased, while the IgA, IgM, and IgG contents increased in response to L-theanine. It is possible that L-theanine affects the P38 signalling pathway and inhibits the increase in p-P65/P65 caused by the overexpression of HSP27 and regulation of PPAR-γ and Foxp3 proteins, thereby alleviating immune dysfunction caused by heat stress.
Topics & Concepts
Immune systemTheanineOxidative stressChemistryp38 mitogen-activated protein kinasesPharmacologyMAPK/ERK pathwayBiochemistryImmunologyMedicineSignal transductionFood scienceGreen teaExercise and Physiological ResponsesTea Polyphenols and EffectsTryptophan and brain disorders