HTE and machine learning-assisted development of iridium(<scp>i</scp>)-catalyzed selective O–H bond insertion reactions toward carboxymethyl ketones
Yougen Xu, Feixiao Ren, Lebin Su, Zhaoping Xiong, Xinwei Zhu, Xinyuan Lin, Nan Qiao, Hao Tian, Chang-En Tian, Kuangbiao Liao
Abstract
By combining HTE and machine learning technologies, an iridium( i )-catalyzed highly selective O–H bond insertion reaction of carboxylic acids and sulfoxonium ylides was developed, and an extensive reaction space exploration was accomplished.
Topics & Concepts
ChemistryIridiumCatalysisCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis