Discovery of 6-aryl-2-(3,4,5-trimethoxyphenyl)thiazole[3,2-b][1,2,4]triazoles as potent tubulin polymerization inhibitors
Na Li, Qi Guan, Yilang Hong, Bowen Zhang, Mi Li, Xuewen Li, Bo Li, Lan Wu, Xuewen Li, Xuewen Li, Bo Li, Lan Wu, Weige Zhang
Topics & Concepts
TubulinChemistryColchicineMicrotubuleThiazoleCytotoxicityStereochemistryMicrotubule polymerizationBinding siteBiochemistryIn vitroCell biologyBiologyGeneticsSynthesis and biological activityCancer Mechanisms and TherapySynthesis and Biological Evaluation