Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells
Tomohiko Shirakawa, Takashi Toyono, Asako Inoue, Takuma Matsubara, T. Kawamoto, Shoichiro Kokabu
Abstract
MyoD, Myf5, myogenin, and MRF4 (also known as Myf6 or herculin) are myogenic regulatory factors (MRFs). MRFs are regarded as master transcription factors that are upregulated during myogenesis and influence stem cells to differentiate into myogenic lineage cells. In this review, we summarize MRFs, their regulatory factors, such as TLE3, NF-κB, and MRF target genes, including non-myogenic genes such as taste receptors. Understanding the function of MRFs and the physiology or pathology of satellite cells will contribute to the development of cell therapy and drug discovery for muscle-related diseases.
Topics & Concepts
MYF5MyoDMyogeninMyogenesisMyogenic regulatory factorsBiologyCell biologyStem cellSkeletal muscleTranscription factorMyocyteMyoD ProteinGeneGeneticsEndocrinologyMuscle Physiology and DisordersGenetics, Aging, and Longevity in Model OrganismsAdipose Tissue and Metabolism