An integrated 1D breathing lung simulation with relative hysteresis of airway structure and regional pressure for healthy and asthmatic human lungs
Su-Jin Yoon, Tran Minh Tam, Prathish K. Rajaraman, Ching‐Long Lin, Merryn H. Tawhai, Eric A. Hoffman, Sanghun Choi
Abstract
This study introduces a one-dimensional (1D) computational fluid dynamics (CFD) model mimicking the realistic changes in diameter and length in whole airways and reveals differences in lung deformation between healthy and asthmatic subjects. Utilizing computational models, the effects of parenchymal inertance and airway wall compliance are investigated by changing ventilation frequency and airway wall elastance, respectively.
Topics & Concepts
LungAirwayBreathingHysteresisHuman lungMedicineAirway hyperresponsivenessRespiratory systemAnesthesiaInternal medicinePhysicsQuantum mechanicsInhalation and Respiratory Drug DeliveryRefrigeration and Air Conditioning TechnologiesGas Dynamics and Kinetic Theory