Physiologically based pharmacokinetic–pharmacodynamic modeling for prediction of vonoprazan pharmacokinetics and its inhibition on gastric acid secretion following intravenous/oral administration to rats, dogs and humans
Weimin Kong, Binbin Sun, Zhongjian Wang, Xiaoke Zheng, Kaijing Zhao, Chen Yang, Jiaxin Zhang, Pei-hua Liu, Liang Zhu, Rujun Xu, Ping Li, Li Liu, Xiaodong Liu
Topics & Concepts
PharmacokineticsPhysiologically based pharmacokinetic modellingPharmacologyPharmacodynamicsStomachChemistryOral administrationGastric acidIn vitroMedicineBiochemistryGastroesophageal reflux and treatmentsHelicobacter pylori-related gastroenterology studiesInflammatory mediators and NSAID effects