Genome-guided discovery of cancer therapeutic targets
Prathyusha Konda, Simon Garinet, Eliezer M. Van Allen, Srinivas R. Viswanathan
Abstract
The success of precision oncology-which aims to match the right therapies to the right patients based on molecular status-is predicated on a robust pipeline of molecular targets against which therapies can be developed. Recent advances in genomics and functional genetics have enabled the unbiased discovery of novel molecular targets at scale. We summarize the promise and challenges in integrating genomic and functional genetic landscapes of cancer to establish the next generation of cancer targets.
Topics & Concepts
Computational biologyGenomicsCancerFunctional genomicsGenomePrecision medicineBiologyBioinformaticsMedicineGeneticsGeneCancer Genomics and DiagnosticsProtein Degradation and InhibitorsCRISPR and Genetic Engineering