Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis
Wei‐Yu Chen, Yi‐Hsiu Wu, Tzu‐Hsien Tsai, Ru-Fang Li, Alan Chuan‐Ying Lai, Lung‐Chih Li, Jenq‐Lin Yang, Ya‐Jen Chang
Abstract
Our findings indicate the presence of IL-33-responsive ILC2s in cardiac tissue and that IL-33-mediated ILC2 expansion affords optimal cardioprotective function via ILC2-derived factors. IL-33-mediated immunomodulation is thus a promising strategy to promote tissue repair and alleviate cardiac fibrosis following acute cardiac injury.
Topics & Concepts
Innate lymphoid cellFibrosisCardiac fibrosisInnate immune systemImmunologyMedicinePathologyImmune systemIL-33, ST2, and ILC PathwaysEosinophilic Esophagitis