Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects
Shicheng Xu, An-ping Guo, Nannan Chen, Wei Dai, Huanaoyu Yang, Wenqin Xie, Mengjie Wang, Qidong You, Xiaoli Xu
Topics & Concepts
ChemistryHsp90Heat shock proteinIn vivoLead compoundPharmacologyColitisAnti-inflammatoryBiochemistryIn vitroGeneImmunologyBiotechnologyBiologyMedicineHeat shock proteins researchthermodynamics and calorimetric analysesATP Synthase and ATPases Research