Induction of Native c-di-GMP Phosphodiesterases Leads to Dispersal of Pseudomonas aeruginosa Biofilms
Jens Bo Andersen, Kasper Nørskov Kragh, Louise Dahl Hultqvist, Morten Rybtke, Martin Nilsson, Tim Holm Jakobsen, Michael Givskov, Tim Tolker‐Nielsen
Abstract
A decade of research has shown that the molecule c-di-GMP functions as a central second messenger in many bacteria. A high level of c-di-GMP is associated with biofilm formation, whereas a low level of c-di-GMP is associated with a planktonic single-cell bacterial lifestyle. c-di-GMP is formed by diguanylate cyclases and is degraded by specific phosphodiesterases.
Topics & Concepts
Pseudomonas aeruginosaBiofilmMicrobiologyChemistryBiological dispersalPhosphodiesterasePseudomonadalesPseudomonadaceaeBiologyBacteriaBiochemistryMedicineGeneticsEnzymePopulationEnvironmental healthBacterial biofilms and quorum sensingAntifungal resistance and susceptibilityAntibiotic Resistance in Bacteria