Is antimicrobial resistance evolution accelerating?
Christopher Witzany, Sebastian Bonhoeffer, Jens Rolff
Abstract
Globally, antimicrobials are a main pillar of medical, veterinary, and agriculture interventions In all cases, resistance of microbes against antimicrobials is prevalent. The problem is exacerbated by the drying up of the antibiotic pipeline, as economic incentives to develop new drugs are very limited. In antifungals, the range of available compounds is also low with only 4 main classes of drugs available to treat fungal infections in humans and 6 main classes used in agriculture, with 1 class, the azoles, used in both
Topics & Concepts
Antibiotic resistanceDaptomycinAntibioticsAntimicrobialIntensive care medicineDrug resistanceResistance (ecology)BiologyMedicineBiotechnologyMicrobiologyBacteriaGeneticsVancomycinEcologyStaphylococcus aureusPharmaceutical and Antibiotic Environmental ImpactsEvolution and Genetic DynamicsAntibiotic Resistance in Bacteria