Nobiletin alleviates macrophage M2 polarization by activating AMPK-mTOR-mediated autophagy in pulmonary fibrosis mice
Yumeng Cheng, Xiaofeng Mei, Wenbo Shao, Jiaping Zheng, Xiaohong Yin, Qin Zhang, Jiansheng Li, Peng Zhao
Topics & Concepts
AutophagyAMPKMacrophage polarizationPI3K/AKT/mTOR pathwayNobiletinPulmonary fibrosisFibrosisMacrophageChemistryPhosphorylationCell biologyMedicineCancer researchBiologySignal transductionInternal medicineProtein kinase AApoptosisBiochemistryFlavonoidIn vitroAntioxidantBioactive Compounds in PlantsInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisPlant-derived Lignans Synthesis and Bioactivity