BRCA1 Mutational Complementation Induces Synthetic Viability
Joseph Nacson, Daniela Di Marcantonio, Yifan Wang, Andrea J. Bernhardy, Emma Clausen, Hua Xiang, Kathy Q. Cai, Esteban Martı́nez, Wanjuan Feng, Elsa Callén, Wei Wu, Gaorav P. Gupta, Joseph R. Testa, André Nussenzweig, Stephen M. Sykes, Neil Johnson
Topics & Concepts
BiologyRAD51ComplementationFanconi anemiaLoss of heterozygosityMutantHomologous recombinationGeneticsHaematopoiesisMutationDNA repairHeterozygote advantageMolecular biologyCell biologyAlleleCancer researchDNAGeneStem cellDNA Repair MechanismsCRISPR and Genetic EngineeringPARP inhibition in cancer therapy