Physiological changes and compensatory mechanisms by the action of respiratory muscles in a porcine model of phrenic nerve injury
Antonella LoMauro, Andréa Aliverti, Gaetano Perchiazzi, Peter Frykholm
Abstract
This was the first (to our knowledge) implanted porcine model of phrenic nerve injury with a detailed multidimensional analysis of different degrees of diaphragmatic paralysis (unilateral and bilateral). Noninvasive thoracoabdominal volume and asynchrony assessment was shown to be useful in estimating the extent of diaphragmatic dysfunction and the consequent coordinated reorganization of nondiaphragmatic respiratory muscles. High level of pressure support ventilation was proved to obscure the interaction and compensation of respiratory muscles to deal with phrenic nerve injury.
Topics & Concepts
Phrenic nerveRespiratory systemDiaphragmatic breathingAnesthesiaMedicineVentilation (architecture)ParalysisDiaphragm (acoustics)AnatomySurgeryPathologyPhysicsAcousticsAlternative medicineLoudspeakerMechanical engineeringEngineeringRespiratory Support and MechanismsCongenital Diaphragmatic Hernia StudiesCardiac Arrest and Resuscitation