Neutrophil reduction attenuates the severity of lung injury in the early phase of pneumococcal pneumonia in mice
Hiroki Taenaka, Xiaohui Fang, Mazharul Maishan, Alpa Trivedi, Katherine D. Wick, Jeffrey E. Gotts, Thomas Martin, Carolyn S. Calfee, Michael A. Matthay
2024American Journal of Physiology-Lung Cellular and Molecular Physiology15 citationsDOIOpen Access PDF
Abstract
Neutrophil accumulation is a key feature of ARDS, but their contribution to the pathogenesis is still uncertain. We investigated the effect of reducing neutrophils in a clinically relevant mouse model of pneumococcal pneumonia treated with antibiotics. When appropriate antibiotics were administered, neutrophil reduction with Ly6G antibody markedly attenuated lung injury and improved oxygenation. In the early phase of bacterial pneumonia, neutrophils contribute to the severity of lung injury, although they also participate in host defense.
Topics & Concepts
Pneumococcal pneumoniaPneumoniaMedicineARDSStreptococcus pneumoniaeLungImmunologyBacterial pneumoniaPneumolysinDiffuse alveolar damageInflammationAntibioticsMicrobiologyBiologyInternal medicineAcute respiratory distressImmune Response and InflammationImmune cells in cancerNeutrophil, Myeloperoxidase and Oxidative Mechanisms