Nickel Catalyzed Carbonylation/Carboxylation Sequence via Double CO<sub>2</sub> Incorporation
Riccardo Giovanelli, Lorenzo Lombardi, Riccardo Pedrazzani, Magda Monari, Marta Castiñeira Reis, Carlos Silva López, Giulio Bertuzzi, Marco Bandini
Abstract
High Resolution Image Download MS PowerPoint Slide A carbonylation–carboxylation synthetic sequence, via double CO 2 fixation, is described. The productive merger of a Ni-catalyzed cross-electrophile coupling manifold, with the use of AlCl 3, triggered a cascade reaction with the formation of three consecutive C–C bonds in a single operation. This strategy traces an unprecedented synthetic route to ketones under Lewis acid assisted carbon dioxide valorization. Computational insights revealed a unique double function of AlCl 3, and labeling ( 13 CO 2 ) experiments validate the genuine incorporation of CO 2 in both functional groups.