Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior
Ainhoa Bilbao, Daniela Neuhofer, Marja D. Sepers, Shoupeng Wei, Manuela Eisenhardt, Sarah Hertle, Olivier Lassalle, Almudena Ramos, Nagore Puente, Raissa Lerner, Aurore Thomazeau, Pedro Grandes, Beat Lutz, Olivier J. Manzoni, Rainer Spanagel
Abstract
mGluR5 mice. The data suggest a model where the eCB and glutamatergic systems of the NAc act in concert to mediate reward-seeking responses.
Topics & Concepts
Endocannabinoid systemNucleus accumbensMedium spiny neuronNeuroscienceMetabotropic glutamate receptor 5DopamineGlutamatergicReward systemBrain stimulation rewardCannabinoid receptorNeurochemicalGlutamate receptorSynaptic plasticityMetabotropic glutamate receptorMetabotropic receptorPharmacologyChemistryBiologyStriatumReceptorBiochemistryAgonistCannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research