Structure–activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors
Guanglin Luo, Ling Chen, Swanee Jacutin-Porte, Ying Han, Catherine R. Burton, Hong Xiao, Carol Krause, Yang Cao, Nengyin Liu, Kevin Kish, H.A. Lewis, John E. Macor, Gene M. Dubowchik
Topics & Concepts
ChemistryGSK-3Structure–activity relationshipIn vivoAmideStereochemistryKinaseGSK3BPyridineLead compoundPhosphoramidateBiochemistryIn vitroMedicinal chemistryBiologyBiotechnologyWnt/β-catenin signaling in development and cancerRNA and protein synthesis mechanismsCancer-related gene regulation