A potent and selective anti-glutathione peroxidase 4 nanobody as a ferroptosis inducer
Xinyu Li, Yaru Li, Aowei Xie, Fenglin Chen, Jing Wang, Jianfeng Zhou, Ximing Xu, Zhenlin Xu, Yong Wang, Xue Qiu
Abstract
gene knocked out. The new GPX4-inhibiting nanobody described here exhibits superior proteome-wide selectivity and a vastly improved safety profile compared to existing GPX4 inhibitors. These incredible features of 12E, as an anti-GPX4 nanobody, may not only contribute to ferroptosis-related anticancer treatment but also establish a new paradigm for nanobodies in drug development for traditionally undruggable targets.
Topics & Concepts
InducerPeroxidaseChemistryGlutathioneGPX4Glutathione peroxidaseBiochemistryCombinatorial chemistryEnzymeGeneFerroptosis and cancer prognosisInflammatory mediators and NSAID effectsAdvanced Nanomaterials in Catalysis