A <i>Streptococcus</i> Quorum Sensing System Enables Suppression of Innate Immunity
Kate M. Rahbari, Jennifer C. Chang, Michael J. Federle
Abstract
Streptococcus pyogenes is restricted to human hosts and commonly causes superficial diseases such as pharyngitis; it can also cause severe and deadly manifestations including necrotizing skin disease or severe postinfectious sequelae like rheumatic heart disease. Understanding the complex mechanisms used by this pathogen to manipulate host defenses could aid in developing new therapeutics to treat infections.
Topics & Concepts
Streptococcus pyogenesQuorum sensingInnate immune systemMicrobiologyTumor necrosis factor alphaBiologyBacteriaBiofilmMacrophageImmune systemImmunityEffectorImmunologyIn vitroStaphylococcus aureusGeneticsStreptococcal Infections and TreatmentsAntimicrobial Resistance in StaphylococcusInfections and bacterial resistance