A first update on mapping the human genetic architecture of COVID-19
COVID-19 Host Genetics Initiative, COVID-19 Host Genetics Initiative, Leadership, Gita A. Pathak, Juha Karjalainen, Christine Stevens, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Writing group, Writing group lead, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Analysis group, Manuscript analyses team lead, Manuscript analyses team members: PHEWAS, Renato Polimanti, Manuscript analyses team members: Mendelian randomization, Nadia V. Harerimana, Manuscript analyses team members: methods development, Matti Pirinen, Manuscript analyses team members: PC projection, gene prioritization, Project management group, Project management lead, Rachel G. Liao, Project managment support, Karolina Chwiałkowska, Amy Trankiem, Mary K. Balaconis, Website development, Huy Nguyen, Matthew Solomonson, Scientific communication group, Scientific communication lead, Kumar Veerapen, Brooke Wolford, Analysis Team Lead, Genevieve Roberts, Data collection lead, Danny Park, Admin team lead, Catherine A. Ball, Analysis team member, Marie V. Coignet, Shannon McCurdy, Spencer C. Knight, Raghavendran Partha, Brooke Rhead, Data collection member, Miao Zhang, Nathan Berkowitz, Michael Gaddis, Keith Noto, Luong Ruiz, Miloš Pavlović, Admin team member, Eurie L. Hong, Kristin A. Rand, Ahna R. Girshick, Harendra Guturu, Asher Haug Baltzell, BelCovid, Analysis team lead, Mari Niemi, Data collection lead, Souad Rahmouni, Julien Guntz, Admin team lead, Y Beguin, Analysis team member, Mattia Cordioli, Sara Pigazzini, Lindokuhle Nkambule, Data collection member, Michel Georges, Michel Moutschen, Benoît Misset, Gilles Darcis, Julien Guiot, Samira Azarzar, Stéphanie Gofflot, Sabine Claassen, Olivier Malaise, Pascale Huynen, Christelle Meuris, Marie Thys, Jessica Jacques, Philippe Léonard, Frédéric Frippiat, Jean‐Baptiste Giot, Anne-Sophie Sauvage, Christian Von Frenckell, Yasmine Belhaj, Bernard Lambermont, Biobanque Quebec COVID-19, Analysis team lead, Tomoko Nakanishi, Data collection lead, David Morrison
Abstract
The COVID-19 pandemic continues to pose a major public health threat,\nespecially in countries with low vaccination rates. To better understand\nthe biological underpinnings of SARS-CoV-2 infection and COVID-19\nseverity, we formed the COVID-19 Host Genetics Initiative1\n. Here we\npresent a genome-wide association study meta-analysis of up to 125,584\ncases and over 2.5 million control individuals across 60 studies from\n25 countries, adding 11 genome-wide significant loci compared with\nthose previously identified2\n. Genes at new loci, including SFTPD, MUC5B\nand ACE2, reveal compelling insights regarding disease susceptibility\nand severity