Pd-Catalyzed Assembly of Fluoren-9-ones by Merging of C–H Activation and Difluorocarbene Transfer
Xiaobing Liu, Heyun Sheng, Yao Zhou, Qiuling Song
Abstract
We disclose a novel Pd-catalyzed assembly of fluoren-9-ones by merging of C–H activation and difluorocarbene transfer. ClCF2COONa served as a difluorocarbene precursor to be harnessed as a carbonyl source in this transformation. The current protocol enables us to afford fluoren-9-ones in high yields with excellent functional group compatibility, which also represents the first example of using difluorocarbene as a coupling partner in transition-metal-catalyzed C–H activation.
Topics & Concepts
DifluorocarbeneCatalysisChemistryPhotochemistryMedicinal chemistryOrganic chemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms