Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction
Torsten P. M. Scheithauer, Hilde Herrema, Hongbing Yu, Guido J. Bakker, Maaike Winkelmeijer, Galina Soukhatcheva, Derek L. Dai, Caixia Ma, Stefan R. Havik, Manon Balvers, Mark Davids, Abraham S. Meijnikman, Ömrüm Aydin, Bert‐Jan H. van den Born, Marc G. Besselink, Olivier R. Busch, Maurits de Brauw, Arnold van de Laar, Clara Belzer, Martin Ståhl, Willem M. de Vos, Bruce A. Vallance, Max Nieuwdorp, C. Bruce Verchere, Daniël H. van Raalte
Abstract
in mice. We postulate that increased systemically disseminated flagellin in T2D is a contributing factor to beta-cell failure in time and represents a novel therapeutic target.
Topics & Concepts
FlagellinBiologyTLR5InflammationGut floraPancreatic isletsIn vivoBeta cellType 2 diabetesProinsulinImmunologyInternal medicineInsulinIsletEndocrinologyMicrobiologyCancer researchDiabetes mellitusReceptorTLR2MedicineTLR4GeneticsPancreatic function and diabetesDiabetes Management and ResearchDiabetes and associated disorders