Alkanes in Minisci-Type Reaction under Photocatalytic Conditions with Hydrogen Evolution
Loris Laze, Beatriz Quevedo-Flores, Irene Bosque, José C. González‐Gómez
Abstract
High Resolution Image Download MS PowerPoint Slide We report herein a protocol for the selective activation of C( sp 3 )–H bonds based on the interplay of two readily available organic catalysts and their successful implementation in cross-coupling azaarenes with alkanes. This Minisci-like reaction is promoted by visible light at room temperature and is free from chemical oxidants, metals, and chlorinated solvents. A wide range of substrates are compatible, including some bioactive molecules. Mechanistic studies support a dual catalytic cycle with H 2 evolution.
Topics & Concepts
ChemistryCatalysisPhotocatalysisMoleculeCombinatorial chemistryPhotochemistryCatalytic cycleReaction conditionsHydrogen bondOrganic chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions