Nitrophenyl-Group-Containing Heterocycles. I. Synthesis, Characterization, Crystal Structure, Anticancer Activity, and Antioxidant Properties of Some New 5,6,7,8-Tetrahydroisoquinolines Bearing 3(4)-Nitrophenyl Group
Eman M. Sayed, Reda Hassanien, Nasser Farhan, Hanan F. Aly, Khaled Mahmoud, Shaaban K. Mohamed, Joel T. Mague, Etify A. Bakhite
Abstract
was determined by X-ray diffraction analysis. In addition, the biological evaluation of some synthesized compounds as anticancer agents was performed, and only six compounds showed moderate to strong activity against PACA2 (pancreatic cancer cell line) and A549 (lung carcinoma cell line). Moreover, the antioxidant properties of most synthesized compounds were examined. The results revealed high antioxidant activity for the most tested compounds.
Topics & Concepts
ChemistryArylIodideTetrahydroisoquinolineEthanolMedicinal chemistryAntioxidantIsoquinolineCancer cell linesOrganic chemistryStereochemistryNuclear chemistryAlkylCancer cellCancerMedicineInternal medicineSynthesis and biological activitySynthesis of heterocyclic compoundsSynthesis and Biological Activity