Sequence-directed dynamic covalent assembly of base-4-encoded oligomers
Samuel Leguizamon, Megan F. Dunn, Timothy F. Scott
Abstract
As an information-bearing biomacromolecule, DNA is encoded in base-4, where each residue site can be occupied by any one of four nucleobases. Mimicking the information dense, sequence-selective hybridization of DNA, we demonstrate two orthogonal dynamic covalent interactions to effect the selective assembly of molecular ladders and grids from base-4-encoded oligo(peptoid)s.
Topics & Concepts
PeptoidCovalent bondNucleobaseDNABase pairSequence (biology)ChemistryResidue (chemistry)Base sequenceStereochemistryNanotechnologyCombinatorial chemistryBiochemistryMaterials sciencePeptideOrganic chemistryAdvanced biosensing and bioanalysis techniquesSupramolecular Self-Assembly in MaterialsLuminescence and Fluorescent Materials