LCZ696 Possesses a Protective Effect Against Homocysteine (Hcy)-Induced Impairment of Blood–Brain Barrier (BBB) Integrity by Increasing Occludin, Mediated by the Inhibition of Egr-1
Wenfeng Li, Wenjin Yuan, Dandan Zhang, Shuchun Cai, Jun Luo, Kanghua Zeng
Topics & Concepts
OccludinBlood–brain barrierOxidative stressHomocysteineNeuroprotectionPharmacologyTight junctionGlutathioneEndothelial dysfunctionMalondialdehydeMedicineChemistryInternal medicineBiochemistryCentral nervous systemEnzymeBarrier Structure and Function StudiesNeurological Disease Mechanisms and TreatmentsFolate and B Vitamins Research