Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis
Yunus Akkoç, Kubilay Dalcı, Hacer Ezgi Karakaş Schüller, Secil Erbil-Bilir, Orçun Yalav, Gürhan Sakman, Faruk Çelik, Soykan Arıkan, Ümit Zeybek, Melek Ergin, Hikmet Akkız, Ece Dilege, Jörn Dengjel, Işın Doğan Ekici, Devrim Gözüaçık
Abstract
ACTA2/α-SMA: actin, alpha 2, smooth muscle CAFs: cancer- or carcinoma-associated fibroblasts CNT Ab.: control antibody CNTF: ciliary neurotrophic factor CTF1: cardiotrophin 1 CTF1 Neut. Ab.: CTF1-specific neutralizing antibody GFP-LC3 MEF: GFP-fused to MAP1LC3 protein transgenic MEF LIF: leukemia inhibitory factor IL6: interleukin 6 MEFs: mouse embryonic fibroblasts MEF-WT: wild-type MEFs OSM: oncostatin M TGFB/TGFβ: transforming growth factor beta.
Topics & Concepts
AutophagyBiologyMediatorStromaMetastasisCancer researchBreast cancerCell migrationCancerCellCell biologyImmunologyApoptosisImmunohistochemistryGeneticsBiochemistryAutophagy in Disease and TherapyHistone Deacetylase Inhibitors ResearchAdenosine and Purinergic Signaling