Single-Molecule Förster Resonance Energy Transfer-Based Photosensitizer for Synergistic Photodynamic/Photothermal Therapy
Yang Zou, Saran Long, Tao Xiong, Xueze Zhao, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng
Abstract
. This strategy exhibits a broad absorption peak with strong light-harvesting ability, which improves photon utilization for treatment while realizing fluorescence imaging. Of note, owing to the smFRET effect, we achieve a combination treatment outcome at relatively low concentrations and light doses. Thus, we believe that this design concept will provide a new strategy for single-molecule FRET photosensitizers in combination therapy of cancer with potential clinical application prospects.
Topics & Concepts
Förster resonance energy transferPhotothermal therapyPhotodynamic therapyPhotosensitizerSinglet oxygenFluorescencePhotochemistryIn vivoChemistryFluorophoreEnergy transferFluorescence-lifetime imaging microscopyPhotothermal effectBiophysicsNanotechnologyMaterials scienceOpticsOxygenBiologyPhysicsMolecular physicsBiotechnologyOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials